癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-DDX50 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q9BQ39 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB8345 |
| Calculated MW | 82565 Da |
| Gene Name | DDX50 |
| Aliases | DDX50; DExD-Box Helicase 50; RH-II/GuB; GU2; GUB; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 50; ATP-Dependent RNA Helicase DDX50; DEAD-Box Helicase 50; DEAD Box Protein 50; MGC3199; Gu-Beta; Malignant Cell Derived RNA Helicase; RNA Helicase II/Gu Beta; Nucleolar Protein GU2; Nucleolar Protein Gu2; EC 3.6.4.13; EC 3.6.1; Mcdrh |
| Immunogen | Recombinant protein of human DDX50 |
| Gene ID | 79009 |
|---|---|
| Other Names | ATP-dependent RNA helicase DDX50, 3.6.4.13, DEAD box protein 50, Gu-beta, Nucleolar protein Gu2, DDX50 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DDX50 |
|---|---|
| Function | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). |
| Cellular Location | Nucleus, nucleolus. Cytoplasm Note=Accumulates in the cytoplasm to activate signaling upstream of IRF3 during viral infection. |
| Tissue Location | Highest expression in skeletal muscle, liver, heart, placenta, and kidney. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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