癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-PSMA6 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P60900 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB13270 |
| Calculated MW | 27399 Da |
| Gene Name | PSMA6 |
| Aliases | PSMA6; Proteasome 20S Subunit Alpha 6; PROS27; P27K; IOTA; Proteasome (Prosome, Macropain) Subunit, Alpha Type, 6; Multicatalytic Endopeptidase Complex Iota Chain; Proteasome Subunit Alpha Type-6; Proteasome Subunit Alpha 6; 27 KDa Prosomal Protein; Proteasome Iota Chain; Macropain Iota Chain; MGC22756; MGC23846; MGC2333; PROS-27; Testicular Secretory Protein Li 44; Proteasome Subunit Alpha1; Proteasome Subunit Iota; Macropain Subunit Iota; Proteasome Subunit Α1; Prosomal P27K Protein; EC 3.4.25.1 |
| Immunogen | Recombinant protein of human PSMA6 |
| Gene ID | 5687 |
|---|---|
| Other Names | Proteasome subunit alpha type-6, 27 kDa prosomal protein, PROS-27, p27K, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain, Proteasome subunit alpha-1, alpha-1, PSMA6 (HGNC:9535), PROS27 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PSMA6 (HGNC:9535) |
|---|---|
| Synonyms | PROS27 |
| Function | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9QUM9, ECO:0000269|PubMed:12181345}. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951) Colocalizes with TRIM5 in cytoplasmic bodies (By similarity) {ECO:0000250|UniProtKB:Q9QUM9, ECO:0000269|PubMed:34711951} |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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