癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-WD Repeat Domain 77 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9BQA1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB13355 |
| Calculated MW | 36724 Da |
| Gene Name | WDR77 |
| Aliases | WDR77; WD Repeat Domain 77; MEP50; Methylosome Protein 50; P44; WD Repeat-Containing Protein 77; Androgen Receptor Cofactor P44; Methylosome Protein WDR77; P44/Mep50; MEP-50; Testis Tissue Sperm-Binding Protein Li 44a; Nbla10071; HKMT1069; WD45 |
| Immunogen | Recombinant protein of human WDR77 |
| Gene ID | 79084 |
|---|---|
| Other Names | Methylosome protein WDR77, Androgen receptor cofactor p44, Methylosome protein 50 {ECO:0000312|HGNC:HGNC:29652}, MEP-50, WD repeat-containing protein 77 {ECO:0000312|HGNC:HGNC:29652}, p44/Mep50, WDR77 (HGNC:29652) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | WDR77 (HGNC:29652) |
|---|---|
| Function | Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334). |
| Cellular Location | Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors (PubMed:17437848). |
| Tissue Location | Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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