癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-BNIP3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q12983 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB13585 |
| Calculated MW | 21541 Da |
| Gene Name | BNIP3 |
| Aliases | BNIP3; BCL2 Interacting Protein 3; HABON; Nip3; BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 3; Hypoxia-Activated BNIP3 Overlapping Non-Coding RNA; BCL2/Adenovirus E1B 19kDa Interacting Protein 3; Nineteen KD Interacting Protein-3; BCL2/Adenovirus E1B Interacting Protein 3; NIP3 |
| Immunogen | A synthesized peptide derived from human BNIP3 |
| Gene ID | 664 |
|---|---|
| Other Names | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, BNIP3 (HGNC:1084), NIP3 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | BNIP3 (HGNC:1084) |
|---|---|
| Synonyms | NIP3 |
| Function | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. |
| Cellular Location | Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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