癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-IFNGR1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P15260 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB13660 |
| Calculated MW | 54405 Da |
| Gene Name | IFNGR1 |
| Aliases | IFNGR1; Interferon Gamma Receptor 1; CD119; IFN-Gamma Receptor 1; IFN-Gamma-R-Alpha; CD119 Antigen; IFN-Gamma-R1; CDw119; IFNGR; Interferon-Gamma Receptor Alpha Chain; Interferon Gamma Receptor Alpha-Chain; Immune Interferon Receptor 1; Antiviral Protein, Type 2; AVP, Type 2; IMD27A; IMD27B |
| Immunogen | A synthesized peptide derived from human IFNGR1 |
| Gene ID | 3459 |
|---|---|
| Other Names | Interferon gamma receptor 1 {ECO:0000312|HGNC:HGNC:5439}, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma-R-alpha, CD119, IFNGR1 (HGNC:5439) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IFNGR1 (HGNC:5439) |
|---|---|
| Function | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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