癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-NPC2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P61916 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB13695 |
| Calculated MW | 16570 Da |
| Gene Name | NPC2 |
| Aliases | NPC2; NPC Intracellular Cholesterol Transporter 2; HE1; EDDM1; Niemann-Pick Disease Type C2 Protein; Human Epididymis-Specific Protein 1; Epididymal Protein 1; NP-C2; Epididymis Secretory Sperm Binding Protein; Tissue-Specific Secretory Protein; Epididymal Secretory Protein E1; Niemann-Pick Disease, Type C2; He1 |
| Immunogen | Recombinant protein of human Niemann Pick C2 |
| Gene ID | 10577 |
|---|---|
| Other Names | NPC intracellular cholesterol transporter 2 {ECO:0000312|HGNC:HGNC:14537}, Epididymal secretory protein E1, Human epididymis-specific protein 1, He1, Niemann-Pick disease type C2 protein, NPC2 (HGNC:14537), HE1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NPC2 (HGNC:14537) |
|---|---|
| Synonyms | HE1 |
| Function | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531, PubMed:18772377, PubMed:29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity). |
| Cellular Location | Secreted. Endoplasmic reticulum. Lysosome Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes. |
| Tissue Location | Detected in gallbladder bile (PubMed:21315718). Detected in fibroblasts, kidney, liver, spleen, small intestine, placenta and testis (at protein level) (PubMed:11125141). Epididymis |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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