癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-COPS3 Rabbit Polyclonal Antibody
Rabbit polyclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9UNS2 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47873 Da |
| Gene Name | COPS3 |
| Aliases | COPS3; COP9 Signalosome Subunit 3; SGN3; CSN3; JAB1-Containing Signalosome Subunit 3; COP9 Signalosome Complex Subunit 3; Signalosome Subunit 3; COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 3; COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis); COP9 Constitutive Photomorphogenic Homolog Subunit 3; COP9 Complex Subunit 3 |
| Immunogen | A synthesized peptide derived from human COPS3 |
| Gene ID | 8533 |
|---|---|
| Other Names | COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3, COPS3, CSN3 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | COPS3 |
|---|---|
| Synonyms | CSN3 |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (PubMed:28891468). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (PubMed:28891468). |
| Cellular Location | Cytoplasm. Nucleus. Cell junction |
| Tissue Location | Widely expressed. Expressed at high level in heart and skeletal muscle. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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