癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-UBE2T Rabbit Polyclonal Antibody
Rabbit polyclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9NPD8 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22521 Da |
| Gene Name | UBE2T |
| Aliases | UBE2T; Ubiquitin Conjugating Enzyme E2 T; HSPC150; FANCT; Cell ProlifeRation-Inducing Gene 50 Protein; Ubiquitin-Conjugating Enzyme E2 T; E2 Ubiquitin-Conjugating Enzyme T; Ubiquitin Carrier Protein T; Ubiquitin-Protein Ligase T; HSPC150 Protein Similar To Ubiquitin-Conjugating Enzyme; Ubiquitin-Conjugating Enzyme E2T (Putative); Ubiquitin-Conjugating Enzyme E2T; Ubiquitin Conjugating Enzyme E2T; EC 2.3.2.23; PIG50 |
| Immunogen | A synthesized peptide derived from human UBE2T |
| Gene ID | 29089 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 T, 2.3.2.23, Cell proliferation-inducing gene 50 protein, E2 ubiquitin-conjugating enzyme T, Ubiquitin carrier protein T, Ubiquitin-protein ligase T, UBE2T |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | UBE2T |
|---|---|
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386). |
| Cellular Location | Nucleus. Note=Accumulates to chromatin |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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