癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-PPM1B Mouse Monoclonal Antibody
Mouse monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O75688 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB13970 |
| Calculated MW | 52643 Da |
| Gene Name | PPM1B |
| Aliases | PPM1B; Protein Phosphatase, Mg2+/Mn2+ Dependent 1B; PP2CB; PPC2BETAX; PP2CBETA; Protein Phosphatase 1B; EC 3.1.3.16; PP2C-Beta; Protein Phosphatase 1B (Formerly 2C), Magnesium-Dependent, Beta Isoform; Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B; Protein Phosphatase 2C, Beta Isoform; Protein Phosphatase 2C-Like Protein; Protein Phosphatase 2C Isoform Beta; PP2C-Beta-X |
| Immunogen | Recombinant protein of human PPM1B |
| Gene ID | 5495 |
|---|---|
| Other Names | Protein phosphatase 1B, 3.1.3.16, Protein phosphatase 2C isoform beta, PP2C-beta, PPM1B, PP2CB |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PPM1B |
|---|---|
| Synonyms | PP2CB |
| Function | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1- mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. |
| Cellular Location | Cytoplasm, cytosol. Membrane {ECO:0000250|UniProtKB:P36993}; Lipid-anchor {ECO:0000250|UniProtKB:P36993}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization {ECO:0000250|UniProtKB:P36993} |
| Tissue Location | Highly expressed in heart and skeletal muscle. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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