癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-PDCL3 Mouse Monoclonal Antibody
Mouse monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9H2J4 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 24GB14085 |
| Calculated MW | 27614 Da |
| Gene Name | PDCL3 |
| Aliases | PDCL3; Phosducin Like 3; VIAF1; Viral IAP-Associated Factor 1; Phosducin-Like Protein 3; HTPHLP; VIAF-1; PhPL3; IAP-Associated Factor VIAF1; PHLP2A; PhLP2A; PHLP3; VIAF |
| Immunogen | Recombinant protein of human PDCL3 |
| Gene ID | 79031 |
|---|---|
| Other Names | Phosducin-like protein 3, HTPHLP, PhPL3, Viral IAP-associated factor 1, VIAF-1, PDCL3, PhLP2A, VIAF1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PDCL3 |
|---|---|
| Synonyms | PhLP2A, VIAF1 |
| Function | Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430). |
| Cellular Location | Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum |
| Tissue Location | Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430). |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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