癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-RNF31 Mouse Oligoclonal Antibody
Mouse oligoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q96EP0 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Oligoclonal |
| Isotype | Mouse IgG |
| Calculated MW | 119652 Da |
| Gene Name | RNF31 |
| Aliases | RNF31; Ring Finger Protein 31; ZIBRA; HOIP; HOIL-1-Interacting Protein; Paul; Zinc In-Between-RING-Finger Ubiquitin-Associated Domain Protein; RING-Type E3 Ubiquitin Transferase RNF31; E3 Ubiquitin-Protein Ligase RNF31; FLJ1011; FLJ23501; RING Finger Protein 31; EC 2.3.2.31; IMD115 |
| Immunogen | Recombinant protein of human RNF31 |
| Gene ID | 55072 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase RNF31, 2.3.2.31, HOIL-1-interacting protein, HOIP, RING finger protein 31 {ECO:0000312|HGNC:HGNC:16031}, RING-type E3 ubiquitin transferase RNF31, Zinc in-between-RING-finger ubiquitin-associated domain protein, RNF31 (HGNC:16031) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RNF31 (HGNC:16031) |
|---|---|
| Function | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa- B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q924T7}. |
| Tissue Location | Expressed in both normal and transformed breast epithelial cell lines. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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