癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-IKBKG Mouse Monoclonal Antibody
Mouse monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9Y6K9 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB14145 |
| Calculated MW | 48198 Da |
| Gene Name | IKBKG |
| Aliases | IKBKG; Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma; IKK-Gamma; IKKAP1; FIP-3; NEMO; FIP3; IKKG; IkB Kinase-Associated Protein 1; NF-Kappa-B Essential Modulator; I-Kappa-B Kinase Subunit Gamma; IkB Kinase Subunit Gamma; ZC2HC9; Fip3p; Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Gamma; Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Gamma; 14.7K (Adenovirus E3 Protein) Interacting Protein 3; NF-Kappa-B Essential Modifier; Incontinentia Pigmenti; IP1; IP2; Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Gamma; AMCBX1; EDAID1; IMD33; SAIDX ; IPD2; IP |
| Immunogen | Recombinant protein of human IKBKG |
| Gene ID | 8517 |
|---|---|
| Other Names | NF-kappa-B essential modulator, NEMO, FIP-3, IkB kinase-associated protein 1, IKKAP1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modifier, IKBKG (HGNC:5961), FIP3, NEMO |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IKBKG (HGNC:5961) |
|---|---|
| Synonyms | FIP3, NEMO |
| Function | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys- 27'-linked polyubiquitination (PubMed:20724660). |
| Cellular Location | Cytoplasm. Nucleus Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. |
| Tissue Location | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
