癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-STK4 Rabbit Monoclonal Antibody
Rabbit monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q13043 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB90 |
| Calculated MW | 55630 Da |
| Gene Name | STK4 |
| Aliases | STK4; Serine/Threonine Kinase 4; MST1; KRS2; YSK3; Mammalian STE20-Like Protein Kinase 1; Serine/Threonine-Protein Kinase Krs-2; Serine/Threonine-Protein Kinase 4; Kinase Responsive To Stress 2; Mammalian Sterile 20-Like 1; STE20-Like Kinase MST1; EC 2.7.11.1; Hippo (Drosophila) Homolog; Yeast Ste20-Like; Hippo Homolog; EC 2.7.11; MST-1 |
| Immunogen | A synthesized peptide derived from human Serine/threonine-protein kinase 4 |
| Gene ID | 6789 |
|---|---|
| Other Names | Serine/threonine-protein kinase 4, 2.7.11.1, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2, Serine/threonine-protein kinase 4 37kDa subunit, MST1/N, Serine/threonine-protein kinase 4 18kDa subunit, MST1/C, STK4 (HGNC:11408) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | STK4 (HGNC:11408) |
|---|---|
| Function | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR- chromatin complexes. |
| Cellular Location | Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm |
| Tissue Location | Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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