癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-KDM2A Rabbit Monoclonal Antibody
Rabbit monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9Y2K7 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB160 |
| Calculated MW | 132793 Da |
| Gene Name | KDM2A |
| Aliases | KDM2A; Lysine Demethylase 2A; JHDM1A; FBL11; CXXC8; FBL7; F-Box And Leucine-Rich Repeat Protein 11; KIAA1004; LILINA; FBXL11; JmjC Domain-Containing Histone Demethylation Protein 1A; Jumonji C Domain-Containing Histone Demethylase 1A; [Histone-H3]-Lysine-36 Demethylase 1A; Lysine (K)-Specific Demethylase 2A; CXXC-Type Zinc Finger Protein 8; Lysine-Specific Demethylase 2A; F-Box/LRR-Repeat Protein 11; DKFZP434M1735; EC 1.14.11.27; FLJ00115; F-Box Protein Lilina; F-Box Protein FBL11; F-Box Protein FBL7 |
| Immunogen | A synthesized peptide derived from human FBXL11 |
| Gene ID | 22992 |
|---|---|
| Other Names | Lysine-specific demethylase 2A, 1.14.11.27, CXXC-type zinc finger protein 8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, JmjC domain-containing histone demethylation protein 1A, [Histone-H3]-lysine-36 demethylase 1A, KDM2A |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KDM2A |
|---|---|
| Function | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically- independent manner (PubMed:26037310). |
| Cellular Location | Nucleus, nucleoplasm. Chromosome Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region (PubMed:19001877, PubMed:20417597). Specifically nucleates at CpG islands where its presence results in chromatin depleted in H3K36me2 (PubMed:19001877, PubMed:20417597) |
| Tissue Location | Widely expressed, with highest levels in brain, testis and ovary, followed by lung. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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