癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-HEXIM1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | O94992 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 25GB650 |
| Calculated MW | 40623 Da |
| Gene Name | HEXIM1 |
| Aliases | HEXIM1; HEXIM P-TEFb Complex Subunit 1; HIS1; MAQ1; EDG1; Hexamethylene Bis-Acetamide-Inducible Protein 1; Hexamethylene Bisacetamide Inducible 1; Estrogen Down-Regulated Gene 1 Protein; Cardiac Lineage Protein 1; Menage A Quatre Protein 1; Protein HEXIM1; CLP-1; CLP1; Hexamethylene-Bis-Acetamide-Inducible Transcript 1; Hexamethylene Bisacetamide-Inducible Protein; Hexamethylene Bis-Acetamide Inducible 1; Hexamthylene Bis-Acetamide Inducible 1; Menage A Quatre 1; HMBA-Inducible |
| Immunogen | Recombinant protein of human HEXIM1 |
| Gene ID | 10614 |
|---|---|
| Other Names | Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HEXIM1 |
|---|---|
| Synonyms | CLP1, EDG1, HIS1, MAQ1 |
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). |
| Cellular Location | Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050) |
| Tissue Location | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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