癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-TFAP2C Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q92754 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB885 |
| Calculated MW | 49177 Da |
| Gene Name | TFAP2C |
| Aliases | TFAP2C; Transcription Factor AP-2 Gamma; AP2-GAMMA; TFAP2G; HAP-2g; ERF1; Activating Enhancer-Binding Protein 2 Gamma; Estrogen Receptor Factor 1; Transcription Factor ERF-1; Transcription Factor AP-2 Gamma (Activating Enhancer-Binding Protein 2 Gamma); AP2-Gamma |
| Immunogen | Recombinant protein of human TFAP2C |
| Gene ID | 7022 |
|---|---|
| Other Names | Transcription factor AP-2 gamma, AP2-gamma, Activating enhancer-binding protein 2 gamma, Transcription factor ERF-1, TFAP2C |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TFAP2C |
|---|---|
| Function | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). |
| Cellular Location | Nucleus. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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