癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-LAMB1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | P07942 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB1590 |
| Calculated MW | 198038 Da |
| Gene Name | LAMB1 |
| Aliases | LAMB1; Laminin Subunit Beta 1; Laminin Subunit Beta-1; Laminin B1 Chain; Laminin, Beta 1; CLM; Cutis Laxa With Marfanoid Phenotype; Laminin-10 Subunit Beta; Laminin-12 Subunit Beta; Laminin-1 Subunit Beta; Laminin-2 Subunit Beta; Laminin-6 Subunit Beta; Laminin-8 Subunit Beta; LIS5 |
| Immunogen | A synthesized peptide derived from human LAMB1 |
| Gene ID | 3912 |
|---|---|
| Other Names | Laminin subunit beta-1, Laminin B1 chain, Laminin-1 subunit beta, Laminin-10 subunit beta, Laminin-12 subunit beta, Laminin-2 subunit beta, Laminin-6 subunit beta, Laminin-8 subunit beta, LAMB1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LAMB1 |
|---|---|
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex (PubMed:23472759). It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons (By similarity). Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface (By similarity). As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway (By similarity). |
| Cellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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