癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-LLGL1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q15334 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4695 |
| Calculated MW | 115418 Da |
| Gene Name | LLGL1 |
| Aliases | LLGL1; LLGL Scribble Cell Polarity Complex Component 1; Lgl1; Mgl1; DLG4; HUGL; LLGL; Lethal Giant Larvae Homolog 1, Scribble Cell Polarity Complex Component; Lethal(2) Giant Larvae Protein Homolog 1; Human Homolog To The D-Lgl Gene Protein; HUGL-1; HUGL1; LLGL1, Scribble Cell Polarity Complex Component; Lethal Giant Larvae Homolog 1 (Drosophila); Hugl-1 |
| Immunogen | Recombinant protein of human LLGL1 |
| Gene ID | 3996 |
|---|---|
| Other Names | Lethal(2) giant larvae protein homolog 1, LLGL, DLG4, Hugl-1, Human homolog to the D-lgl gene protein, LLGL1, DLG4, HUGL, HUGL1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LLGL1 |
|---|---|
| Synonyms | DLG4, HUGL, HUGL1 |
| Function | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. |
| Cellular Location | Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developing axons (By similarity). |
| Tissue Location | Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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