癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-TPX2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9ULW0 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4765 |
| Calculated MW | 85653 Da |
| Gene Name | TPX2 |
| Aliases | TPX2; TPX2 Microtubule Nucleation Factor; HCA519; DIL-2; P100; Hepatocellular Carcinoma-Associated Antigen 519; Targeting Protein For Xklp2; C20orf1; C20orf2; FLS353; Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2; Differentially Expressed In Cancerous And Noncancerous Lung Cells 2; Hepatocellular Carcinoma-Associated Antigen 90; Protein Fls353; DIL2; Restricted Expression Proliferation Associated Protein 100; Restricted Expression Proliferation-Associated Protein 100; TPX2, Microtubule-Associated, Homolog (Xenopus Laevis); Preferentially Expressed In Colorectal Cancer; TPX2, Microtubule-Associated Protein Homolog; Differentially Expressed In Lung Cells; TPX2, Microtubule-Associated, Homolog; Chromosome 20 Open Reading Frame 1; TPX2, Microtubule-Associated; GD:C20orf1; REPP86; HCTP4 |
| Immunogen | A synthesized peptide derived from human TPX2 |
| Gene ID | 22974 |
|---|---|
| Other Names | Targeting protein for Xklp2, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Hepatocellular carcinoma-associated antigen 519, Hepatocellular carcinoma-associated antigen 90, Protein fls353, Restricted expression proliferation-associated protein 100, p100, TPX2, C20orf1, C20orf2, DIL2, HCA519 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TPX2 |
|---|---|
| Synonyms | C20orf1, C20orf2, DIL2, HCA519 |
| Function | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. |
| Tissue Location | Expressed in lung carcinoma cell lines but not in normal lung tissues |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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