癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-WWOX Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9NZC7 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4780 |
| Calculated MW | 46677 Da |
| Gene Name | WWOX |
| Aliases | WWOX; WW Domain Containing Oxidoreductase; SDR41C1; WOX1; FOR; WW Domain-Containing Oxidoreductase; Short Chain Dehydrogenase/Reductase Family 41C Member 1; Fragile Site FRA16D Oxidoreductase; Short Chain Dehydrogenase/Reductase Family 41C, Member 1; WW Domain-Containing Protein WWOX; EC 1.1.1.-; D16S432E; EC 1.1.1; HHCMA56; PRO0128; EIEE28; FRA16D; SCAR12; DEE28 |
| Immunogen | Recombinant protein of human WWOX |
| Gene ID | 51741 |
|---|---|
| Other Names | WW domain-containing oxidoreductase, 1.1.1.-, Fragile site FRA16D oxidoreductase, Short chain dehydrogenase/reductase family 41C member 1, WWOX, FOR, SDR41C1, WOX1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | WWOX |
|---|---|
| Synonyms | FOR, SDR41C1, WOX1 |
| Function | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
| Cellular Location | Cytoplasm. Nucleus Mitochondrion. Golgi apparatus. Lysosome Note=Partially localizes to the mitochondria (PubMed:14695174) Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus Localized to the lysosome probably upon binding to VOPP1 (PubMed:30285739). {ECO:0000250, ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:30285739} |
| Tissue Location | Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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