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>   首页   >   KD-Validated Anti-NFKBIE Rabbit Monoclonal Antibody   

KD-Validated Anti-NFKBIE Rabbit Monoclonal Antibody

Rabbit monoclonal antibody

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O00221
Reactivity Human
Clonality Monoclonal
Isotype Rabbit IgG
Clone Names 25GB4800
Calculated MW 52864 Da
Gene Name NFKBIE
Aliases NFKBIE; NFKB Inhibitor Epsilon; IKBE; NF-Kappa-B Inhibitor Epsilon; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Epsilon; I-Kappa-B-Epsilon; IkappaBepsilon; NF-Kappa-BIE; IkB-Epsilon; IkB-E
Immunogen A synthesized peptide derived from human NFKBIE
Additional Information
Gene ID 4794
Other Names NF-kappa-B inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon, NFKBIE, IKBE

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name NFKBIE
Synonyms IKBE
Function Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50- c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity).
Cellular Location Cytoplasm.
Tissue Location Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages
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