癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-PRKRA Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, ICC |
|---|---|
| Primary Accession | O75569 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2340 |
| Calculated MW | 34404 Da |
| Gene Name | PRKRA |
| Aliases | PRKRA; Protein Activator Of Interferon Induced Protein Kinase EIF2AK2; PACT; RAX; Protein Activator Of The Interferon-Induced Protein Kinase; PKR-Associated Protein X ; HSD14 ; DYT16; Interferon-Inducible Double-Stranded RNA-Dependent Protein Kinase Activator A; Protein Kinase, Interferon-Inducible Double-Stranded RNA-Dependent Activator; PKR-Associating Protein X; Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator |
| Immunogen | A synthesized peptide derived from human PRKRA |
| Gene ID | 8575 |
|---|---|
| Other Names | Interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X, PKR-associating protein X, Protein activator of the interferon-induced protein kinase, Protein kinase, interferon-inducible double-stranded RNA-dependent activator, PRKRA, PACT, RAX |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PRKRA (HGNC:9438) |
|---|---|
| Synonyms | PACT, RAX |
| Function | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys- 386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). May function as regulator of gastric epithelial differentiation (By similarity). |
| Cellular Location | Cytoplasm, perinuclear region. Cytoplasm. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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