癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-C-terminal Src kinase Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, ICC |
|---|---|
| Primary Accession | P41240 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 1920 |
| Calculated MW | 50704 Da |
| Gene Name | CSK |
| Aliases | CSK; C-Terminal Src Kinase; CSK, Non-Receptor Tyrosine Kinase; Tyrosine-Protein Kinase CSK; Protein-Tyrosine Kinase CYL; C-Src Tyrosine Kinase; C-Src Kinase; EC 2.7.10.2; EC 2.7.10 |
| Immunogen | A synthesized peptide derived from human CSK |
| Gene ID | 1445 |
|---|---|
| Other Names | Tyrosine-protein kinase CSK, 2.7.10.2, C-Src kinase, Protein-tyrosine kinase CYL, CSK |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CSK |
|---|---|
| Function | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. May act as a negative regulator of EGFR and STAT3 signaling pathways (PubMed:26918609). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P41241}. Cell membrane {ECO:0000250|UniProtKB:P41241}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250|UniProtKB:P41241} |
| Tissue Location | Expressed in lung and macrophages. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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