癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-NUMB Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P49757 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB940 |
| Calculated MW | 70804 Da |
| Gene Name | NUMB |
| Aliases | NUMB Endocytic Adaptor Protein; C14orf41; Protein Numb Homolog; H-Numb; Chromosome 14 Open Reading Frame 41; Numb (Drosophila) Homolog; Numb Homolog (Drosophila); Numb Homolog; Protein S171; C14_5527; S171 |
| Immunogen | A synthesized peptide derived from human NUMB |
| Gene ID | 8650 |
|---|---|
| Other Names | Protein numb homolog, h-Numb, Protein S171, NUMB (HGNC:8060) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NUMB (HGNC:8060) |
|---|---|
| Function | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). |
| Cellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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