癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Cathepsin B Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, ICC |
|---|---|
| Primary Accession | P07858 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 1130 |
| Calculated MW | 37822 Da |
| Gene Name | CTSB |
| Aliases | CTSB; Cathepsin B; APP Secretase; Cathepsin B1; EC 3.4.22.1; APPS; CPSB; Keratolytic Winter Erythema (Oudtshoorn Skin Disease); Epididymis Secretory Sperm Binding Protein; Amyloid Precursor Protein Secretase; Cysteine Protease; EC 3.4.22; RECEUP; KWE |
| Immunogen | A synthesized peptide derived from human Cathepsin B |
| Gene ID | 1508 |
|---|---|
| Other Names | Cathepsin B, 3.4.22.1, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CTSB |
|---|---|
| Synonyms | CPSB |
| Function | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). |
| Cellular Location | Lysosome. Melanosome. Secreted, extracellular space {ECO:0000250|UniProtKB:A1E295}. Apical cell membrane {ECO:0000250|UniProtKB:P10605}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10605}; Extracellular side {ECO:0000250|UniProtKB:P10605}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity) {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:17081065} |
| Tissue Location | Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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