癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KO-Validated Anti-FERMT2 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q96AC1 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 24GB6195 |
| Calculated MW | 77861 Da |
| Gene Name | FERMT2 |
| Aliases | FERMT2; FERM Domain Containing Kindlin 2; KIND2; UNC112B; PLEKHC1; Mig-2; Pleckstrin Homology Domain Containing, Family C (With FERM Domain) Member 1; PH Domain-Containing Family C Member 1; Fermitin Family Homolog 2; Mitogen Inducible Gene-2; Fermitin Family Member 2; Kindlin-2; MIG2; Pleckstrin Homology Domain Containing, Family C Member 1; Pleckstrin Homology Domain-Containing Family C Member 1; Fermitin Family Homolog 2 (Drosophila); Mitogen Inducible Gene 2 Protein; Mitogen-Inducible Gene 2 Protein; Kindlin 2; UNC112; MIG-2 |
| Immunogen | Recombinant protein of human FERMT2 |
| Gene ID | 10979 |
|---|---|
| Other Names | Fermitin family homolog 2, Kindlin-2, Mitogen-inducible gene 2 protein, MIG-2, Pleckstrin homology domain-containing family C member 1, PH domain-containing family C member 1, FERMT2, KIND2, MIG2, PLEKHC1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FERMT2 |
|---|---|
| Synonyms | KIND2, MIG2, PLEKHC1 |
| Function | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
| Cellular Location | Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band. Cell surface. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides |
| Tissue Location | Ubiquitous. Found in numerous tumor tissues. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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