癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KO-Validated Anti-TRIM7 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9C029 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 25GB690 |
| Calculated MW | 56631 Da |
| Gene Name | TRIM7 |
| Aliases | TRIM7; Tripartite Motif Containing 7; GNIP; Glycogenin-Interacting Protein; E3 Ubiquitin-Protein Ligase TRIM7; Tripartite Motif Protein TRIM7; RING Finger Protein 90; Tripartite Motif-Containing Protein 7; Tripartite Motif-Containing 7; EC 2.3.2.27 |
| Immunogen | Recombinant protein of human TRIM7 |
| Gene ID | 81786 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM7, 2.3.2.27, Glycogenin-interacting protein, RING finger protein 90, Tripartite motif-containing protein 7, TRIM7, GNIP, RNF90 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TRIM7 |
|---|---|
| Synonyms | GNIP, RNF90 |
| Function | E3 ubiquitin-protein ligase that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration (PubMed:25851810, PubMed:32853985, PubMed:34062120). Acts as an antiviral effector against multiple viruses by targeting specific viral proteins for ubiquitination and degradation including norovirus NTPase protein or SARS-CoV-2 NSP5 and NSP8 proteins (PubMed:34062120, PubMed:35982226). Mechanistically, recognizes the C-terminal glutamine-containing motif usually generated by viral proteases that process the polyproteins and trigger their ubiquitination and subsequent degradation (PubMed:35867826, PubMed:35893676, PubMed:35982226). Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of pro-inflammatory cytokines and type I interferon (By similarity). Also plays a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). Mediates the ubiquitination of the SIN3- HDAC chromatin remodeling complex component BRMS1 (PubMed:32853985). Modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells by ubiquitinating NCOA4, leading to its degradation (PubMed:36067704). |
| Cellular Location | Nucleus. Cytoplasm. Golgi apparatus |
| Tissue Location | Skeletal muscle and placenta, at lower levels in heart, brain and pancreas. Isoform 1 is widely expressed with high level in testis, kidney and heart. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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