癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KO-Validated Anti-Serine/Threonine Kinase 3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q13188 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3265 |
| Calculated MW | 56301 Da |
| Gene Name | STK3 |
| Aliases | STK3; Serine/Threonine Kinase 3; MST2; KRS1; Serine/Threonine Kinase 3 (Ste20, Yeast Homolog); Mammalian STE20-Like Protein Kinase 2; Serine/Threonine-Protein Kinase Krs-1; Serine/Threonine-Protein Kinase 3; STE20-Like Kinase MST2; EC 2.7.11.1; MST-2; Serine/Threonine Kinase 3 (STE20 Homolog, Yeast); Epididymis Secretory Sperm Binding Protein; Hippo (Drosophila) Homolog; Hippo Homolog; KB-1458E12.1; EC 2.7.11 |
| Immunogen | A synthesized peptide derived from human STK3 |
| Gene ID | 6788 |
|---|---|
| Other Names | Serine/threonine-protein kinase 3, 2.7.11.1, Mammalian STE20-like protein kinase 2, MST-2, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3 36kDa subunit, MST2/N, Serine/threonine-protein kinase 3 20kDa subunit, MST2/C, STK3 (HGNC:11406) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | STK3 (HGNC:11406) |
|---|---|
| Function | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr- 74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). |
| Cellular Location | Cytoplasm. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (PubMed:11278283, PubMed:19525978) Phosphorylation at Thr-117 leads to inhibition of nuclear translocation (PubMed:19525978). |
| Tissue Location | Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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