癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD50 / ICAM-3 Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM505 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IF, FC, IHC-P |
|---|---|
| Primary Accession | P32942 |
| Other Accession | 3385, 354563 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG2b, kappa |
| Clone Names | SPM505 |
| Calculated MW | 59541 Da |
| Gene ID | 3385 |
|---|---|
| Other Names | Intercellular adhesion molecule 3, ICAM-3, CDw50, ICAM-R, CD50, ICAM3 |
| Application Note | IF~~1:50~200 FC~~1:10~50 IHC-P~~1:50~200 |
| Format | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD50 / ICAM-3 Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ICAM3 (HGNC:5346) |
|---|---|
| Function | Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring apoptotic neutrophil phagocytosis by macrophages (PubMed:1448173, PubMed:1448174, PubMed:23775590, PubMed:8325327, PubMed:8459213). Is also a ligand for integrin ITGAD/ITGB2 (PubMed:8777714). Ligand of CD209 on dendritic cells (DC) through an integrin-independent mechanism that requires Ca(2+) and that forms a first contact between DC and resting T cell, facilitating the downstream DC-T cell clustering process and DC-induced proliferation of resting T Cells (PubMed:10721994). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein Note=Localization at uropodium is mediated through interaction with MSN. |
| Tissue Location | Constitutively expressed only on resting leukocytes (PubMed:8325327). No expressed on resting or cytokine-activated endothelial cells (PubMed:1448174). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Recognizes the D1 domain of an N-glycosylated glycoprotein of 120kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signaling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C. This MAb is excellent for staining of formalin/paraffin tissues.
REFERENCES
LeukocyteTyping V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford (1995)p. 1546-1547, 1578-1579. | C.L. Holness, et al, (1995) J Biol Chem 270: 877-884. | Y. van Kooyk,et al, (1996) J Exp Med 183:1247-1252. | Leukocyte TypingVI (T. Kishimoto, et al, eds.) GarlandPublishing, Inc., New York (1997) p.403-409
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