癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Insulin / IRDN (beta-Cell & Insulinoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM139 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IF, FC, IHC-P |
|---|---|
| Primary Accession | P01308 |
| Other Accession | 3630, 272259 |
| Reactivity | Human, Pig, Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | SPM139 |
| Calculated MW | 11981 Da |
| Gene ID | 3630 |
|---|---|
| Other Names | Insulin, Insulin B chain, Insulin A chain, INS |
| Application Note | IF~~1:50~200 FC~~1:10~50 IHC-P~~N/A |
| Format | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Insulin / IRDN (beta-Cell & Insulinoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INS |
|---|---|
| Function | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
| Cellular Location | Secreted. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
REFERENCES
de la Tour, D., et al. 2001. Mol. Endoc. 15: 476-483. | Rajagopal, J., et al. 2003. Science 299: 363. | Morisset, J., et al. 2003. J. Histochem. Cytochem. 51: 1501-1513
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