癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM489 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IF, IHC-P |
|---|---|
| Primary Accession | P13591 |
| Other Accession | 4684, 503878, P13592 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | SPM489 |
| Calculated MW | 94574 Da |
| Gene ID | 4684 |
|---|---|
| Other Names | Neural cell adhesion molecule 1, N-CAM-1, NCAM-1, CD56, NCAM1, NCAM |
| Application Note | IF~~1:50~200 IHC-P~~N/A |
| Format | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCAM1 (HGNC:7656) |
|---|---|
| Synonyms | NCAM |
| Function | This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. (Microbial infection) Acts as a receptor for Zika virus. |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Cell membrane; Lipid-anchor, GPI- anchor [Isoform 5]: Secreted. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
REFERENCES
Gerardy-Schahn R; et. al. Int Journal of Cancer. Supplement, 1994, 8:38-42. | Michalides R; et. al. International Journal of Cancer. Supplement, 1994, 8:34-7. | K. Moolenaar et al.Cancer Research 50, 1102-1106, 1990 | Schol DJ; et. al. Int J Cancer. Supplement, 1988, 2:34-4
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