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Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPM117 ]

     
  • 2 -  Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide AH10717
    Formalin-fixed, paraffin-embedded human Non-Hodgkin's Lymphoma stained with Bcl-2 Ab (SPM117).
  • 4 -  Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide AH10717
    Flow Cytometry of Jurkat cells using Bcl-2 Ab (SPM117) (red) and isotype control (green).
  • 1 -  Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide AH10717
    Western Blot of Bcl-2 in human Skin using Bcl-2 Ab (SPM117).
Formalin-fixed, paraffin-embedded human Non-Hodgkin's Lymphoma stained with Bcl-2 Ab (SPM117).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, FC, IHC-P
Primary Accession P10415
Other Accession 596, 150749
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM117
Calculated MW 26266 Da
Additional Information
Gene ID 596
Other Names Apoptosis regulator Bcl-2, BCL2
Application Note WB~~1:1000
IF~~1:50~200
FC~~1:10~50
IHC-P~~N/A
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1- inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:P10417}
Tissue Location Expressed in a variety of tissues.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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