癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Ep-CAM / CD326 (Rat) (Epithelial Marker) Antibody - Bioreactor Concentrate
Mouse Monoclonal Antibody [Clone SPM535 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, FC, IP |
|---|---|
| Primary Accession | O55159 |
| Other Accession | 171577 (Rat) |
| Reactivity | Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1 |
| Clone Names | SPM535 |
| Calculated MW | 35207 Da |
| Gene ID | 171577 |
|---|---|
| Other Names | Epithelial cell adhesion molecule, Ep-CAM, Epithelial glycoprotein 314, EGP314, Protein D5.7A, Tumor-associated calcium signal transducer 1, CD326, Epcam, Tacstd1 |
| Application Note | WB~~1:1000 IF~~1:50~200 FC~~1:10~50 IP~~N/A |
| Format | Bioreactor Concentrate with 0.05% Azide. Contact us if you require it in a different format. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Ep-CAM / CD326 (Rat) (Epithelial Marker) Antibody - Bioreactor Concentrate is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Epcam |
|---|---|
| Synonyms | Tacstd1 |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). |
| Cellular Location | Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Epitope of GZ-1 and GZ-20 monoclonal antibodies are different. EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas.
REFERENCES
Litvinov SV et. al. J Cell Biol, 1994, 125:437-46. ,2. Tsubura A et. al. J Cut Pathol, 1992, 19:73-9
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