癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD57 / B3GAT1 (Natural Killer Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone HNK-1 + NK-1 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC, IF |
|---|---|
| Primary Accession | Q9P2W7 |
| Other Accession | 27087, 381050 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgM's |
| Clone Names | HNK-1 + NK-1 |
| Calculated MW | 38256 Da |
| Gene ID | 27087 |
|---|---|
| Other Names | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, 2.4.1.135, Beta-1, 3-glucuronyltransferase 1, Glucuronosyltransferase P, GlcAT-P, UDP-GlcUA:glycoprotein beta-1, 3-glucuronyltransferase, GlcUAT-P, B3GAT1, GLCATP |
| Application Note | IHC~~1:100~500 IF~~1:50~200 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD57 / B3GAT1 (Natural Killer Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | B3GAT1 (HGNC:921) |
|---|---|
| Synonyms | GLCATP |
| Function | Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo- fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl- sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. |
| Cellular Location | [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35789}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O35789}. Secreted {ECO:0000250|UniProtKB:O35789} |
| Tissue Location | Mainly expressed in the brain. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Anti-CD57 marks a subset of lymphocytes known as natural killer (NK) cells. Follicular center cell lymphomas often contain many NK cells within the neoplastic follicles. Anti-CD57 also stains neuroendocrine cells and their derived tumors, including carcinoid tumor and medulloblastoma. Anti-CD57 can also be useful in separating type B3 thymoma from thymic carcinoma when combined with a panel that includes antibodies against GLUT1, CD5, and CEA.
REFERENCES
Abo T et. al. J Immunol, 1982, 129(4):1758-61. | Abo T et al. J Immunology, 1982, 129:1752-7
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