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>   首页   >   产品   >   一抗   >   其他   >    MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide   

MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone MUC1/520 ]

     
  • 2 -  MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide AH11866
    Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with MUC-1 / EMA Monoclonal Antibody (MUC1/520).
  • 2 -  MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide AH11866
    Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC-1 / EMA Monoclonal Antibody (MUC1/520).
  • 2 -  MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide AH11866
    Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with MUC-1 / EMA Monoclonal Antibody (MUC1/520).
  • 2 -  MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide AH11866
    Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with MUC-1 / EMA Monoclonal Antibody (MUC1/520).
  • 2 -  MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide AH11866
    Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with MUC-1 / EMA Monoclonal Antibody (MUC1/520).
  • 2 -  MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide AH11866
    Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with MUC-1 / EMA Monoclonal Antibody (MUC1/520).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC, IF, FC
Primary Accession P15941
Other Accession 4582, 89603
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names MUC1/520
Calculated MW 122102 Da
Additional Information
Gene ID 4582
Other Names Mucin-1, MUC-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, CA 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, KL-6, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin, CD227, Mucin-1 subunit alpha, MUC1-NT, MUC1-alpha, Mucin-1 subunit beta, MUC1-beta, MUC1-CT, MUC1, PUM
Application Note IHC~~1:100~500
IF~~1:50~200
FC~~1:10~50
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MUC1
Synonyms PUM
Function The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
Cellular Location Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells After endocytosis, internalized and recycled to the cell membrane Located to microvilli and to the tips of long filopodial protusions [Isoform Y]: Secreted. [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus
Tissue Location Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinomas. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

REFERENCES

Stanley CM, Phillips TE. Am J Physiol. 1999;277:G191-200

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