癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TGF-beta (Transforming Growth Factor beta) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone 1D11.16.8 ]
- 产品详情
- 实验流程
- 背景知识
| Primary Accession | P01137 |
|---|---|
| Other Accession | 7040 (beta1), 7042 (beta2), 7043 (beta3), 645227, P10600 (beta2), P61812 (beta3) |
| Reactivity | Human, Mouse, Hamster, Monkey, Bovine, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | 1D11.16.8 |
| Calculated MW | 44325 Da |
| Gene ID | 7040 |
|---|---|
| Other Names | Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | TGF-beta (Transforming Growth Factor beta) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TGFB1 (HGNC:11766) |
|---|---|
| Synonyms | TGFB |
| Function | Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. |
| Cellular Location | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix |
| Tissue Location | Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This MAb recognizes TGF beta 1, 2 and 3. Three TGFĪ �s have been identified in mammals. TGFĪ �1, TGFĪ �2 and TGFĪ �3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFĪ � requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFĪ �3 protein has approximately 80% identity to the mature region of both TGFĪ �1 and TGFĪ �2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFĪ �ā€™s inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.Ā
REFERENCES
Dasch JR, Pace DR, Waegell W, Inenaga D, Ellingsworth L. Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. J Immunol. 1989 Mar 1;142(5):1536-41
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