癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD48 (Pan Leukocyte Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone 156-4H9 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IF, FC |
|---|---|
| Primary Accession | P09326 |
| Other Accession | 962, 243564 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | 156-4H9 |
| Calculated MW | 27683 Da |
| Gene ID | 962 |
|---|---|
| Other Names | CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, SLAM family member 2, SLAMF2, Signaling lymphocytic activation molecule 2, TCT.1, CD48, CD48, BCM1, BLAST1 |
| Application Note | IF~~1:50~200 FC~~1:10~50 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD48 (Pan Leukocyte Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD48 |
|---|---|
| Synonyms | BCM1, BLAST1 |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation (PubMed:12007789, PubMed:19494291, PubMed:27249817, PubMed:9841922). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291). In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK- cells (PubMed:27249817). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Secreted |
| Tissue Location | Widely expressed on all hematopoietic cells. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.
REFERENCES
Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, New York and London, 1997. | Yokoyama S et al. Expression of the Blast-1 activation/adhesion molecule and its identification as CD48. J Immunol 1991, 146(7):2192-2200. | Kwong YL et al. Flow cytometric measurement of glycosylphosphatidyl-inositol-linked surface proteins on blood cells of patients with paroxysmal nocturnal hemoglobinuria. Am J Clin Pathol 1994, 102(1):30-35 | Sandrin MS et al. CD48 is a low affinity ligand for human CD2.J Immunol 1993, 151(9):4606-4613. | Vaughan HA et al. The isolation of cDNA clones for CD48. Immunogenetics 1991, 33(2):113-117. | Vaughan HA et al. Hu Ly-M3--a human leukocyte antigen. Transplantation 1983, 36(4):446-450
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