癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone BU69 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IF, FC, IP, E, IHC-F |
|---|---|
| Primary Accession | P32970 |
| Other Accession | 970, 501497, 715224 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | BU69 |
| Calculated MW | 21118 Da |
| Gene ID | 970 |
|---|---|
| Other Names | CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7 |
| Application Note | IF~~1:50~200 FC~~1:10~50 IP~~N/A E~~N/A IHC-F~~N/A |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CD70 (HGNC:11937) |
|---|---|
| Function | Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, PubMed:28011864, PubMed:8387892). The CD70- CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown toĀinhibit T cell proliferation induced by dendritic cells.
REFERENCES
R.Q. Hintzen, et al, (1994) J Immunol 152: 1762-1773. | M.R. Bowman, et al, (1994) J Immunol 152: 1756-1761. | Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138. | K. Agematsu, et al, (1995) J Immunol 154: 3627-3635
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