癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Connexin 32 (Gap Junction Protein) Antibody
Rat Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-F, IF, FC |
|---|---|
| Primary Accession | P28230 |
| Other Accession | 21198 |
| Reactivity | Mouse, Rat |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | Rat / IgG2a |
| Clone Names | R5.21C |
| Calculated MW | 32004 Da |
| Gene ID | 14618 |
|---|---|
| Other Names | Charcot Marie Tooth neuropathy X linked; CMTX; CMTX1; Connexin-32; Cx32; GAP junction 28kDa liver protein; Gap junction beta-1 protein; Gap junction protein beta 1 32kD; GJB1 |
| Application Note | Immunofluorescence (1-2ug/ml); ,Flow Cytometry (0.5-1ug/million cells);,Western Blotting (0.5-1ug/ml); ,Immunohistology (Frozen) (0.5-1.0ug/ml for 30 minutes at RT),Optimal dilution for a specific application should be determined. |
| Format | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Anti-Connexin 32 (Gap Junction Protein) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Gjb1 |
|---|---|
| Synonyms | Cxn-32 |
| Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This Ab recognizes a protein of 27-32kDa, identified as Connexin 32. The connexin family of proteins forms hexameric complexes called connexons that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino-acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20-connexin isoforms produces channels with distinct permeability and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another.
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