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ZNF274 antibody - N-terminal region
Rabbit Polyclonal Antibody
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- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q96GC6 |
| Other Accession | Q96GC6-3, NP_057408, NM_016324 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Bovine |
| Predicted | Rabbit, Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74177 Da |
| Gene ID | 10782 |
|---|---|
| Alias Symbol | DKFZp686K08243, HFB101, ZF2, ZKSCAN19 |
| Other Names | Neurotrophin receptor-interacting factor homolog, Zinc finger protein 274, Zinc finger protein HFB101, Zinc finger protein with KRAB and SCAN domains 19, Zinc finger protein zfp2, Zf2, ZNF274, ZKSCAN19 |
| Target/Specificity | ZNF274 is a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus.This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-ZNF274 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ZNF274 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF274 |
|---|---|
| Synonyms | ZKSCAN19 |
| Function | Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). |
| Cellular Location | Cytoplasm. Nucleus, nucleolus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This is a rabbit polyclonal antibody against ZNF274. It was validated on Western Blot and immunohistochemistry by Abgent. At Abgent we manufacture rabbit polyclonal antibodies on a large scale (200-1000 products/month) of high throughput manner. Our antibodies are peptide based and protein family oriented. We usually provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
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