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RIPX antibody - C-terminal region
Rabbit Polyclonal Antibody
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q7L099 |
| Other Accession | Q7L099, NP_055776, NM_014961 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52965 Da |
| Gene ID | 22902 |
|---|---|
| Alias Symbol | RIPX, SINGAR1 |
| Other Names | Protein RUFY3, Rap2-interacting protein x, RIPx, Single axon-regulated protein, Singar, RUFY3, KIAA0871 |
| Target/Specificity | Located on chromosome 4, the RIPX encodes a protein with unknown function. |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RIPX antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RIPX antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RUFY3 (HGNC:30285) |
|---|---|
| Synonyms | KIAA0871 |
| Function | ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (PubMed:35314674). Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). |
| Cellular Location | Cytoplasm. Endomembrane system. Cell projection, invadopodium. Perikaryon {ECO:0000250|UniProtKB:Q9D394}. Cell projection {ECO:0000250|UniProtKB:Q9D394}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D394}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9D394}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9D394}. Lysosome Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (PubMed:25766321). Colocalizes with Ras-related Rab-5 proteins in cytoplasmic vesicles (PubMed:20376209) Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalizes with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Colocalizes with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity). Recruitment to endolysosomes partially depends upon the presence of ARL8 (PubMed:35314674). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:20376209, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:35314674} |
| Tissue Location | Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This is a rabbit polyclonal antibody against RIPX. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
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