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SMARCAD1 antibody - N-terminal region
Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q9H4L7 |
| Other Accession | Q9H4L7, AAH17953, Q05D56 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 117402 Da |
| Gene ID | 56916 |
|---|---|
| Alias Symbol | DKFZp762K2015, ETL1, KIAA1122, HEL1, ADERM |
| Other Names | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1, ATP-dependent helicase 1, hHEL1, SMARCAD1, KIAA1122 |
| Target/Specificity | SMARCAD1 belongs to the SNF2/RAD54 helicase family. It contains 2 CUE domains, 1 helicase ATP-binding domain, and 1 helicase C-terminal domain. It is a probable ATP-dependent DNA helicase. |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SMARCAD1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SMARCAD1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SMARCAD1 (HGNC:18398) |
|---|---|
| Function | Protein that possesses intrinsic ATP-dependent nucleosome- remodeling activity and is both required for DNA repair and heterochromatin organization (PubMed:22960744, PubMed:21820097). Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes (PubMed:21820097). Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (PubMed:22960744). Required for the restoration of heterochromatin organization after replication (PubMed:21549307). Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (PubMed:21549307). |
| Cellular Location | Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase (PubMed:21549307). Recruited to double-strand breaks (DSBs) sites of DNA damage (PubMed:22960744) |
| Tissue Location | Isoform 1 is expressed ubiquitously. Isoform 3 is expressed mainly in skin and esophagus. Expressed in fibroblasts and keratinocytes (at protein level) (PubMed:29409814) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This is a rabbit polyclonal antibody against SMARCAD1. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
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