癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RBBP9 Antibody
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF |
|---|---|
| Primary Accession | O75884 |
| Other Accession | O75884, NP_006597, NM_006606 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21000 Da |
| Gene ID | 10741 |
|---|---|
| Alias Symbol | BOG, MGC9236, RBBP10 |
| Other Names | Putative hydrolase RBBP9, 3---, B5T-overexpressed gene protein, Protein BOG, Retinoblastoma-binding protein 10, RBBP-10, Retinoblastoma-binding protein 9, RBBP-9, RBBP9, BOG, RBBP10 |
| Target/Specificity | RBBP9 may play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RBBP9 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RBBP9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBBP9 (HGNC:9892) |
|---|---|
| Synonyms | BOG, RBBP10 |
| Function | Serine hydrolase (Probable) (PubMed:32196348). Catalyzes the hydrolytic activation of amino acid ester of the antiviral prodrug valacyclovir to its corresponding active drug, acyclovir (PubMed:32196348). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699). |
| Tissue Location | Expressed at higher levels in tumor tissues such as carcinoma. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This is a rabbit polyclonal antibody against RBBP9. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
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