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Ywhag antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P61982 |
| Other Accession | NM_018871, NP_061359 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Pig, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Zebrafish, Chicken, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28303 Da |
| Gene ID | 22628 |
|---|---|
| Alias Symbol | 14-3-3gamma, D7Bwg1348e |
| Other Names | 14-3-3 protein gamma, 14-3-3 protein gamma, N-terminally processed, Ywhag |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ywhag antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Ywhag antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ywhag {ECO:0000312|MGI:MGI:108109} |
|---|---|
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (By similarity). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (By similarity). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (By similarity). |
| Cellular Location | Cytoplasm, cytosol. Mitochondrion matrix {ECO:0000250|UniProtKB:P61981}. Note=Translocates to the mitochondrial matrix following induction of MALM (mitochondrial protein catabolic process). {ECO:0000250|UniProtKB:P61981} |
| Tissue Location | Expressed in dorsal skin (at protein level). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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