癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Gabra5 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8BHJ7 |
| Other Accession | NM_176942, NP_795916 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Horse, Bovine |
| Predicted | Human, Pig, Chicken, Dog, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52274 Da |
| Gene ID | 110886 |
|---|---|
| Alias Symbol | A230018I05Rik |
| Other Names | Gamma-aminobutyric acid receptor subunit alpha-5, GABA(A) receptor subunit alpha-5, Gabra5 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Gabra5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Gabra5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Gabra5 {ECO:0000312|MGI:MGI:95617} |
|---|---|
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing alpha-5/GABRA5 are mainly extrasynaptic and contribute to the tonic GABAergic inhibition of the hippocampus (PubMed:14993607). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (PubMed:14993607). |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644}. Cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644} |
| Tissue Location | Expressed in brain, in hippocampal pyramidal neurons. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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