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KIF1A antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q12756 |
| Other Accession | NM_004321, NP_004312 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Pig, Dog, Bovine |
| Predicted | Human, Mouse, Zebrafish, Pig, Chicken, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 191064 Da |
| Gene ID | 547 |
|---|---|
| Alias Symbol | ATSV, C2orf20, DKFZp686I2094, FLJ30229, HUNC-104, MGC133285, MGC133286, UNC104, MRD9, HSN2C, SPG30 |
| Other Names | Kinesin-like protein KIF1A, Axonal transporter of synaptic vesicles, Microtubule-based motor KIF1A, Unc-104- and KIF1A-related protein, hUnc-104, KIF1A, ATSV, C2orf20 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-KIF1A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | KIF1A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KIF1A |
|---|---|
| Synonyms | ATSV, C2orf20 |
| Function | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, neuron projection. Cell projection, axon {ECO:0000250|UniProtKB:P33173}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P33173}. Synapse {ECO:0000250|UniProtKB:P33173} Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:F1M4A4}; Peripheral membrane protein {ECO:0000250|UniProtKB:F1M4A4}; Cytoplasmic side {ECO:0000250|UniProtKB:F1M4A4}. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (By similarity). Accumulates at the distal tip of growing neurites. {ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:25265257, ECO:0000269|PubMed:33880452} |
| Tissue Location | Expressed in neurons. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Kikkawa,M. (2006) EMBO J. 25 (18), 4187-4194Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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