癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PARP12 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9H0J9 |
| Other Accession | NM_022750, NP_073587 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Bovine |
| Predicted | Human, Mouse, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 79064 Da |
| Gene ID | 64761 |
|---|---|
| Alias Symbol | FLJ22693, MST109, MSTP109, PARP-12, ZC3H1, ZC3HDC1 |
| Other Names | Poly [ADP-ribose] polymerase 12, PARP-12, 2.4.2.30, ADP-ribosyltransferase diphtheria toxin-like 12, ARTD12, Zinc finger CCCH domain-containing protein 1, PARP12, ZC3HDC1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PARP12 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PARP12 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PARP12 {ECO:0000303|PubMed:20106667, ECO:0000312|HGNC:HGNC:21919} |
|---|---|
| Function | Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252). |
| Cellular Location | Nucleus. Golgi apparatus, trans- Golgi network. Cytoplasm, Stress granule. Note=Translocates from the Golgi complex to stress granules upon stress conditions |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Katoh,M. (2003) Int. J. Oncol. 23 (2), 541-547 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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