癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PDLIM5 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q96HC4 |
| Other Accession | NM_001011513, NP_001011513 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Bovine |
| Predicted | Human, Mouse, Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 63945 Da |
| Gene ID | 10611 |
|---|---|
| Alias Symbol | L9, ENH, LIM, ENH1 |
| Other Names | PDZ and LIM domain protein 5, Enigma homolog, Enigma-like PDZ and LIM domains protein, PDLIM5, ENH |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-PDLIM5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PDLIM5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDLIM5 {ECO:0000303|PubMed:15346770, ECO:0000312|HGNC:HGNC:17468} |
|---|---|
| Function | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. |
| Cellular Location | Postsynaptic density {ECO:0000250|UniProtKB:Q62920}. Presynapse {ECO:0000250|UniProtKB:Q62920}. Postsynapse {ECO:0000250|UniProtKB:Q62920}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62920}. Note=Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons {ECO:0000250|UniProtKB:Q62920} |
| Tissue Location | Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Lasorella,A., et al., (2006) Proc. Natl. Acad. Sci. U.S.A. 103 (13), 4976-4981Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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