癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Ttbk2 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q3UVR3 |
| Other Accession | NM_001024856, NP_001020027 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 136770 Da |
| Gene ID | 140810 |
|---|---|
| Alias Symbol | 2610507N02Rik, AI326283, B930008N24Rik, KIAA0847, TTK, Ttbk, Ttbk1, mKIAA0847 |
| Other Names | Tau-tubulin kinase 2, 2.7.11.1, Protein bartleby, Ttbk2, Bby, Kiaa0847, Ttbk1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ttbk2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Ttbk2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ttbk2 |
|---|---|
| Synonyms | Bby, Kiaa0847, Ttbk1 |
| Function | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (By similarity). Required for recruitment of CPLANE2 and INTU to the mother centriole (PubMed:29038301). |
| Cellular Location | Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6IQ55}. Nucleus {ECO:0000250|UniProtKB:Q6IQ55}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:29038301). May also be present in cytosol and, at lower level in the nucleus (By similarity). {ECO:0000250|UniProtKB:Q6IQ55, ECO:0000269|PubMed:29038301} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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