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Clcn1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P35524 |
| Other Accession | NM_013147, NP_037279 |
| Reactivity | Human, Mouse, Rat, Rabbit, Goat, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 110073 Da |
| Gene ID | 25688 |
|---|---|
| Alias Symbol | SMCC, Clcn1 |
| Other Names | Chloride channel protein 1, ClC-1, Chloride channel protein, skeletal muscle, Clcn1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Clcn1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Clcn1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Clcn1 |
|---|---|
| Function | Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing (By similarity) (PubMed:1659664, PubMed:9565403). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization (By similarity). Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide (PubMed:1659664, PubMed:9565403). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q64347}; Multi-pass membrane protein. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q64347}; Multi-pass membrane protein |
| Tissue Location | Predominantly expressed in skeletal muscles. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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